个人简介

翁郁华，民盟盟员，北京理工大学威廉希尔特别副研究员、硕士研究生导师。研究方向：（1）基于核酸分子的药物与影像探针开发，研究的核酸分子包括小干扰RNA、mRNA、ASO、CRISPR/Cas基因编辑系统、aptamer等；（2）核酸递送技术研究，包括分子缀合技术、外泌体、可降解聚合物、脂质纳米颗粒递送技术等。近五年以第一/通讯作者发表SCI论文十余篇，其中ESI高被引论文3篇，影响因子IF>10分的论文8篇；先后主持国家自然科学基金、北京市自然科学基金等多项项目；获得授权专利2项；是Wiley出版社期刊Exploration的青年编委，多个学术学会的会员。

教育/培训经历

2014.9-2017.6 中国科学院大学&国家纳米科学中心 博士 专业：材料学

2007.9-2010.6 上海师范大学 硕士 专业：微生物学

2003.9-2007.6 信阳师范学院 学士 专业：生物技术

工作经历

2019.10-至今 北京理工大学 威廉希尔（英国威廉希尔公司） 特别副研究员、助理教授

2017.9-2019.9 北京理工大学 前沿交叉科学研究院 博士后

2011.8-2014.8 温州医科大学 眼视光学院、医院 科研人员

2010.7-2011.7 同济大学丽水中药研究院 科研人员

学术任职

Exploration期刊青年编委

研究领域

（1）基于核酸分子的药物与影像探针开发，研究的核酸分子包括小干扰RNA、mRNA、ASO、CRISPR/Cas基因编辑系统、aptamer等；

（2）核酸递送技术研究，包括分子缀合技术、外泌体、可降解聚合物、脂质纳米颗粒递送技术等。

（2）所获奖励/荣誉

2021．12 获北京理工大学2021年度统一战线‘同心’先进个人荣誉称号；

2018．8 获中国科学院第二届“发现科学之美”图片大赛三等奖；

2016．12获国家纳米科学中心第四届微观摄影大赛一等奖；

讲授课程

分子诊断学

教材及专著

1. Yuhua Weng, Yuanyu Huang*. The Advances of Biomacromolecule-based Nanomedicine in Brain Disease. In: Xue Xue (eds) Nanomedicine in Brain Disease. Springer, Singapore. 2019.

参与项目

1. 国家重点研发计划，2021YFA1201000,在研，子课题负责人；

2. 国家自然科学基金，32001008，在研，主持；

3. 北京市自然科学基金，7214302，在研，主持；

4. 国家自然科学基金，31871003，在研，参与；

5. 中国博士后科学基金，2018M630085，已结题，主持；

6. 温州市科技计划项目，Y20130115，已结题， 主持；

7. 科技部国际科技合作重点项目，2012DFB30020，已结题，参与。

SCI Journal paper

1. Yuquan Zhang, Ziyue Li, Julien Milon Essola, Kun Ge, Xuyan Dai, Huining He, Haihua Xiao, Yuhua Weng*, Yuanyu Huang*. Biosafety materials: Ushering in a new era of infectious disease diagnosis and treatment with the CRISPR/Cas system. Biosafety and Health. 2022, 4(2):70-78.

2. Kun Li, Yuquan Zhang, Abid Hussain*, Yuhua Weng*, Yuanyu Huang*. Progress of Photodynamic and RNAi Combination Therapy in Cancer Treatment. ACS Biomaterials Science and Engineering. 2021, 7(9): 4420–4429. (IF=5.395)

3. Chunhui Li#, Tongren Yang#, Yuhua Weng#（equal contribution）, Mengjie Zhang, Deyao Zhao, Shuai Guo, Bo Hu, Wanxuan Shao, Xiaoxia Wang, Abid Hussain, Xing-Jie Liang, Yuanyu Huang*. Ionizable lipid-assisted efficient hepatic delivery of gene editing elements for oncotherapy. Bioactive Materials. 2021, 9:590-601.（IF=16.874）

4. Yuhua Weng, Yuanyu Huang*. Advances of mRNA vaccines for COVID-19: a new prophylactic revolution begins. Asian Journal of Pharmaceutical Sciences. 2021, 16(3): 263-264.（IF=9.273）

5. Tongren Yang#, Chunhui Li#, Xiaoxia Wang#, Deyao Zhao, Mengjie Zhang, Huiqing Cao, Zicai Liang, Haihua Xiao, Xing-Jie Liang, Yuhua Weng*, Yuanyu Huang*. Efficient hepatic delivery and protein expression enabled by optimized mRNA and ionizable lipid nanoparticle. Bioactive Materials. 2020, 5 (4): 1053-1061.（IF=16.874）

6. Yuhua Weng, Chunhui Li, Tongren Yang, Bo Hu, Mengjie Zhang, Shuai Guo, Haihua Xiao, Xing-Jie Liang, Yuanyu Huang*. The challenge and prospect of mRNA therapeutics landscape. Biotechnology Advances. 2020, 40: 107534.（IF=17.681）（ESI高被引论文)

7. Yuhua Weng, Qianqian Huang, Chunhui Li, Yongfeng Yang, Xiaoxia Wang, Jie Yu, Yuanyu Huang*, Xing-Jie Liang*. Improved Nucleic Acid Therapy with Advanced Nanoscale Biotechnology. Molecular Therapy - Nucleic Acids. 2020. 19: 581-601. (IF=10.183)

8. Bo Hu#, Yuhua Weng#(equal contribution), Xin Hua Xia, Xing‐jie Liang, Yuanyu Huang*. Clinical advances of siRNA therapeutics. J Gene Med. 2019, 21 (7): e3097. (IF=4.152)

9. Yuhua Weng, Haihua Xiao, Jinchao Zhang, Xing-Jie Liang, Yuanyu Huang*. RNAi therapeutic and its innovative biotechnological evolution. Biotechnology Advances. 2019, 37 (5): 801-825.（IF=17.681）(ESI高被引论文)

10. Shuquan Zheng#, Xiaoxia Wang#, YuHua Weng#, Xingyu Jin, Jia-Li Ji, Liangxia Guo, Bo Hu, Nan Liu, Qiang Cheng, Jianqi Zhang, Huicheng Bai, Tongren Yang, Xin-Hua Xia, Hong-Yan Zhang, Shan Gao, Yuanyu Huang*. siRNA Knockdown of RRM2 Effectively Suppressed Pancreatic Tumor Growth Alone or Synergistically with Doxorubicin. Molecular Therapy - Nucleic Acids. 2018, 12: 805-816. (IF=10.183)

11. Yuhua Weng#, Xiaowei Ma#, Jing Che, Chan Li, Juan Liu, Shizhu Chen, Yuqin Wang, Yaling Gan, Hao Chen, Zhongbo Hu*, Kaihui Nan*, Xing-jie Liang*. Nanomicelle-assisted targeted ocular delivery with enhanced anti-inflammatory efficacy in vivo. Advanced Science. 2018,5(1):1700455. 18（IF=17.521）

12. Yuhua Weng, Juan Liu, Shubin Jin, Weisheng Guo*, Xing-jie Liang*, Zhongbo Hu*. Nanotechnology-based strategies for treatment of ocular disease. Acta pharmaceutica Sinica B, 2017, 7(3)：281-291. (IF=14.903)（ESI高被引论文）

13. Yuhua Weng, Jing Che, Xiaowei Ma1, Hongbo Guo, Xiangdong Xue, Shizhu Chen, Xu Zhang, Tingbin Zhang, Chan Li, Jing Xu, Yaling Gan, Zhongbo Hu*, Xing-jie Liang*. Contrast enhancement method of TEM visualization for polymeric micelles by fluoride addition and staining. Journal of biomedical nanotechnology. 2017,13, 534–543. (IF=3.641)

EI Journal paper

中文论文

专利

Personal Resume

Assistant Professor, Beijing Institute of Technology (BIT), China

Birthday: 1986.03

Location: Beijing, China

Email: wengyh@bit.edu.cn

Education Background

Ph.D. 2014-2017 Material Science, University of Chinese Academy of Science & National Center for Nano Science and Technology of China

M.Sc. 2007-2010 Microbiology, Shanghai Normal University, China

B.Sc. 2003-2007 Biotechnology, Xinyang Normal University, China

Positions and Employment

2019-present, Assistant Professor, School of Medical Technology, BIT

2017-2019, Postdoctoral Researcher, Advanced Research Institute of Multidisciplinary Science, BIT

2011-2014, Researcher, The eye hospital, Wenzhou Medical University

2010-2011, Researcher, Lishui Institute of traditional Chinese medicine, Tongji University

Professional Membership/Academic Appointments

《Exploration》Academic Editor

Research and Teaching Interest

1.Development of efficient nucleic acid delivery platform technology for treatment of ocular, liver, tumor and other diseases with nucleic acids.

2.Functional nanomedicine with potential clinical diagnosis and treatment prospects.

Honors and Awards