李诺敏 |
特别副研究员 |
学科:生物医学工程/生物学 |
方向:空间生物医学工程/空间神经生物学 |
电子邮件:6120190133@bit.edu.cn |
办公地址:北京市海淀区中关村南大街5号北京理工大学5号教学楼615 |
个人简介
教育/培训经历
2011/9 - 2016/7,北京理工大学,生物化工,博士
2008/9 - 2011/7,军事医学科学院,药理学,硕士
2004/9 - 2008/9,北京理工大学,生物技术,学士
工作经历
2019/9- 至今, 北京理工大学,英国威廉希尔公司,特别副研究员
2016/8 – 2019/7,北京理工大学,生命学院,博士后
2012/8 - 2013/9,美国哈佛医学院,交换生,
研究领域
主要的研究方向为神经生物学,主要的研究重点为航空复合环境对精神行为和认知的影响、神经退行性疾病的相关分子机制研究,从蛋白质组学,修饰组学的手段来阐明航空复合环境对精神认知影响的分子机制。
参与项目
1、国家自然科学基金青年项目,81801073,ZNF335在阿尔兹海默病中的生物学功能研究,2019/01-2021/12,21万,主持
2、国家自然科学基金地区基金项目,31960174,酰胺化苯乙烯促海马神经干细胞生长和抗AD的神经营养作用于机制,2020/01-2023/12,40万,参与
3、国家自然科学基金面上项目,81171206,阿尔茨海默症致病机理中有关的早衰因子对β分泌酶BACE1调控的研究,2012/01-2015/12, 60万元,已结题,参与
4、国家自然科学基金面上项目,81870844,基于靶向蛋白质组学筛选技术的阿尔兹海默病早期诊断生物标志物研究,2019/01-2022/12,56万,参与
SCI Journal paper
1.Nuomin Li# ,Kefu Liu#, Yunjie Qiu, Huanhuan Zhang, Hiroshi Nakanishi, Hong Qing*, Mutations of β-amyloid precursor protein alters the consequence of Alzheimer’s disease pathogenesis. Neural Regeneration Research.2018
2.Jin W, Qazi TJ, Quan Z, Li N*, Qing H*. Dysregulation of Transcription Factors: A Key Culprit Behind Neurodegenerative Disorders. Neuroscientist. 2018 Nov 28
3.Li N, Liu K, Qiu Y, Ren Z, Dai R, Deng Y, Qing H*.Effect of Presenilin Mutations on APP Cleavage; Insights into the Pathogenesis of FAD. Front Aging Neurosci. 2016 Mar 11;8:51.
4.Wang X#, Li N#, Xiong N#, You Q, Li J, Yu J, Qing H, Wang T, Cordell HJ, Isacson O, Vance JM, Martin ER, Zhao Y, Cohen BM, Buttner EA, Lin Z*. Genetic Variants of Microtubule Actin Cross-linking Factor 1 (MACF1) Confer Risk for Parkinson's Disease. Mol Neurobiol. 2017 May;54(4):2878-2888..
5.Xiong N#, Li N#,Martin E, Yu J, Li J, Liu J, Lee DY, Isacson O, Vance J, Qing H, Wang T, Lin Z*. hVMAT2: A target of individualized medication for Parkinson’s disease.Neurotherapeutics. 2016 Jul;13(3):623-34.
6. Wang X, Du J, Wang D, Zeng F, Wei Y, Wang F, Feng C, Li N, Dai R, Deng Y, Quan Z, Qing H*. Effects of simulated microgravity on human brain nervous tissue. Neurosci Lett. 2016 Aug 3;627:199-204.
7. Zhao Y, Xiong N, Liu Y, Zhou Y, Li N, Qing H, Lin Z*. Human dopamine transporter gene: differential regulation of 18-kb haplotypes. Pharmacogenomics. 2013 Sep;14(12):1481-94.
8. Ling H, Li N,Ye N, Zhang J, Yu B, Yang Z*. Anxiolytic effect and receptor binding properties of acetylated tetrahydroberberrabine. Chinese Journal of Pharmacology and Toxicology, 2013, 27(6)
9. Zhao Y, Xiong N, Liu Y, Zhou Y, Li N, Qing H, Lin Z*. Human dopamine transporter gene: differential regulation of 18-kb haplotypes. Pharmacogenomics. 2013 Sep;14(12):1481-94.
专利
Personal Resume
Education Background
Ph.D 2016,Beijing Institute of Technology,Biotechnology
M.S 2011, Academy of Military Medical Sciences,pharmacology
B.A 2008,Beijing Institute of Technology,biotechnology
Positions and Employment
2019.9 -current, assistant professor, Institute of Engineering Medicine, Beijing Institute of Technology
2016/8 – 2019/7,Postdoctoral Researcher,School of Life Science, Beijing Institute of Technology
2012/8 - 2013/9,exchange student,Harvard Medical School,McLean Hospital
Research and Teaching Interest
The main research focuses on the effects of aero composite environment on mental behavior and cognition, and the mechanism of neurodegenerative diseases.